(Test Bank) Pharmacotherapeutics For Advanced Practice

Arcangelo,Peterson, 3

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Test Bank for Pharmacotherapeutics For Advanced Practice, The downloadable file consists of 999 pages, and the total size of the file is 11.35 MB. Purchase now only for highly discounted price.

Author(s): Arcangelo, Peterson

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Pharmacotherapeutics for Advanced Practice A Practical Approach THIRD EDITION Arcangelo_FM.indd iArcangelo_FM.indd i 10/8/2011 2:55:28 PM10/8/2011 2:55:28 PMArcangelo_FM.indd iiArcangelo_FM.indd ii 10/8/2011 2:55:28 PM10/8/2011 2:55:28 PMPharmacotherapeutics for Advanced Practice A Practical Approach THIRD EDITION Editors VIRGINIA POOLE ARCANGELO, PhD, CRNP Family Nurse Practitioner Avocare Gigliotti Family MedicineBerlin, New Jersey ANDREW M. P ETERSON , PharmD, PhD Dean, Mayes College of Healthcare Business and PolicyAssociate Professor of Clinical Pharmacy and Health PolicyUniversity of Sciences in PhiladelphiaPhiladelphia, Pennsylvania Arcangelo_FM.indd iiiArcangelo_FM.indd iii 10/8/2011 2:55:28 PM10/8/2011 2:55:28 PMAcquisitions Editor Bill Lamsback Product Director David Moreau Product Manager Rosanne Hallowell Copy Editor Amy Furman Proofreader Christine Dahlin Editorial Assistants Karen J. Kirk, Jeri O’Shea, Linda K. Ruhf Creative Director Doug Smock Cover Designer David Levy Vendor Managers Beth Martz and Karyn Crislip Manufacturing Manager Beth J. Welsh Production and Indexing Services SPi GlobalThe clinical treatments described and recommended in this publica-tion are based on research and consultation with nursing, medical, and legal authorities. To the best of our knowledge, these procedures reflect currently accepted practice. Nevertheless, they can’t be con-sidered absolute and universal recommendations. For individual applications, all recommendations must be considered in light of the patient’s clinical condition and, before administration of new or infre-quently used drugs, in light of the latest package-insert information. The authors and publisher disclaim any responsibility for any adverse effects resulting from the suggested procedures, from any undetected errors, or from the reader’s misunderstanding of the text. © 2013 by Lippincott Williams & Wilkins.© 2006 and 2001 by Lippincott Williams & Wilkins. All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means—electronic, mechanical, photocopy, recording, or otherwise—without prior written permission of the publisher, except for brief quotations embodied in critical articles and reviews, and test-ing and evaluation materials provided by the publisher to instructors whose schools have adopted its accompanying textbook. For informa-tion, write Lippincott Williams & Wilkins, 323 Norristown Road, Suite 200, Ambler, PA 19002-2756. Printed in ChinaPAP3E010112Library of Congress Cataloging-in-Publication Data Pharmacotherapeutics for advanced practice: a practical approach / [edited by] Andrew M. Peterson, Virginia Poole Arcangelo. — 3rd ed. p. ; cm. Includes bibliographical references and index. ISBN 978-1-4511-1197-2 (pbk.) 1. Chemotherapy. I. Peterson, Andrew M. II. Arcangelo, Virginia Poole. [DNLM: 1. Drug Therapy—methods. 2. Pharmaceutical Preparations—administration & dosage. WB 330] RM262.P4685 2011 615.5¢8—dc22 2011012201 Arcangelo_FM.indd ivArcangelo_FM.indd iv 10/8/2011 2:55:32 PM10/8/2011 2:55:32 PMThis book is in memory of Tony. Without your love and support, this book would never have happened. You will always be remembered and will live in our hearts forever. Death leaves a heartache no one can heal, love leaves a memory no one can steal. —From a headstone in Ireland Arcangelo_FM.indd vArcangelo_FM.indd v 10/8/2011 2:55:32 PM10/8/2011 2:55:32 PMArcangelo_FM.indd viArcangelo_FM.indd vi 10/8/2011 2:55:32 PM10/8/2011 2:55:32 PMviiPREFACE harmacotherapeutics for Advanced Practice originated from our combined experience in teaching nurse prac-titioners. As a nurse practitioner and educator herself, Virginia saw a need for practical exposure to the general prin-ciples of prescribing and monitoring drug therapy, particularly in the Family Practice arena. As a PharmD, Andrew saw a need to be able to teach new prescribers how to think about pre-scribing systematically, regardless of the disease state. We both found no suitable book that combined the practical with the systematic—most of the textbooks dedicated to this topic pro-vided too much basic pharmacology with too little therapeu-tics. This book not only gives the basics on the pharmacology of the drugs, it also provides a process through which learners can begin to think pharmacotherapeutically—that is, learners will begin to identify a disease, review the drugs used to treat the disease, select treatment based on goals of therapy and spe-cial patient considerations, and learn how to adjust therapy if it fails to meet goals. This is a book that meets the needs of both students and practitioners in a practical approach that is user friendly. It teaches the practitioner how to prescribe and manage drug therapy in primary care. The design of the book is based on input from both academicians and practitioners. Contributors were selected from academia and practice to provide a combi-nation of evidence-based medicine and practical experience. The text considers disease- and patient-specific information. With each chapter, there are tables and algorithms that are practical and easy to read and that complement the text. Additionally, the text guides the practitioner to a choice of second- and third-line therapy when the first line of therapy fails. Since new drugs are being marketed at all times, drug categories are discussed and information can be applied to the new drugs. Each chapter ends with a simple case study designed to prompt the learner to think and the teacher to ask critical questions. Also, each case study asks the same ques-tions, reinforcing a clinical decision-making process. There are no answers to the questions since the authors believe the purpose of the case studies is to promote discussion, and that there may be more than one correct answer to each question, especially as new drugs are developed. What’s more, the ques-tions appear in the order in which they would be asked by a practitioner as he or she prescribes a medication. ORGANIZATION OF THE BOOK Unit 1—Principles of Therapeutics The first chapter introduces the prescribing process, including how to avoid medication errors. The next chapter provides the traditional, and necessary, information on the pharmacokinetics and pharmacodynamics of drugs. Using this foundation, the subsequent chapters apply this information to drug–drug and drug–food interactions, and discuss the changes in these param-eters in pediatric, geriatric, and pregnant patients. The remain-ing chapters in the Principles unit give overviews of drugs that are used across many disease states: pain medications and antibiotics. These chapters discuss the principles of pain man-agement and infectious disease therapy, so that the reader can learn how these concepts are applied to the disorders discussed in the following units. A full chapter on Complementary and Alternative Medicine (CAM) is included in this unit, recog-nizing continued use of these modalities and attempting to meet the ever-growing need for information related to this aspect of patient care. New to this unit is a full chapter on Pharmacogenomics—the study of the human genes, effect on drug behavior. The addition of this chapter reflects the rapidly growing need for the clinician to understand how small varia-tions in a person’s genetic makeup can greatly affect how that person responds to drug therapy. While this chapter presents a general overview of this area of study, several of the disorders chapters incorporate this information directly into the clinical decision-making process. Units 2 through 12—Disorders This section of the book, consisting of 40 chapters, reviews commonly seen disorders in the primary care setting. Although not all-inclusive, the array of disorders allows the reader to gain an understanding of how to approach the pharmacotherapeu-tic treatment of any disorder. The chapters are designed to give a brief overview of the disease process, including the causes and pathophysiology, with an emphasis placed on how drug therapy can alter the pathologic state. Diagnostic Criteria and Goals of Therapy are discussed and underlie the basic prin-ciples of treating patients with drugs. The drug sections review the agents’ uses, mechanism of action, contraindications and drug interactions, adverse effects, and monitoring parameters. This discussion is orga-nized primarily by drug class, with notation to specific drugs within the text and the tables. The tables provide the reader with quick access to generic and trade names and dosages, adverse events, contraindications, and special considerations. Used together, the text and tables provide the reader with suf-ficient information to begin to choose a drug therapy for a patient. The section on Selecting the Most Appropriate Agent aids the reader in deciding which agent to choose for a given patient. This section contains information on first-line, second-line, and third-line therapies, with rationales for why agents are classified in these categories. Accompanying this section is an algorithm P Arcangelo_FM.indd viiArcangelo_FM.indd vii 10/8/2011 2:55:32 PM10/8/2011 2:55:32 PMviii PREFACE outlining the thought process by which clinicians select an ini- tial drug therapy. Again, the text organization and the illustrative algorithms provide readers with a means of thinking through the process of selecting drugs for patients. In the third edition, we have kept the Recommended Order of T reatment tables and updated them, along with the algorithms and drug tables, to reflect current knowledge. Each chapter has been updated to reflect the most current guidelines available at the time of writ-ing. However, medicine and pharmacotherapy are constantly changing, and it remains the clinician’s responsibility to deter-mine the most current information. Included in each chapter is a section on monitoring a patient’s response. This encompasses clinical and laboratory parameters, times when these items should be monitored, and actions to take in case the parameters do not meet the specified goals of therapy. In addition, special patient populations are discussed when appropriate. These discussions include pediat-ric and geriatric patients, but may also include ethnic- or sex-related considerations. Last, this section includes a discussion of patient education material relevant to the disease and drugs chosen. In each chapter there is a patient education section that includes information on CAM related to that disorder as well as sections on external information for patients and practitioners. Each of the case studies has been reviewed and updated as appropriate. However, the pedagogical style of reasoning remains the same. Answers to these case studies are not sup-plied since the purpose is to promote discussion and evoke a thought process. Also, as time changes, so do therapies. The cases are short, compelling the learner to ask questions about the patient and allowing flexibility for multiple “right” answers to be developed by the instructor as they work through the clinical decision-making process. Unit 13—Pharmacotherapy in Health Promotion This unit discusses several areas of interest for promoting health or maintaining a healthy lifestyle using medications, including smoking cessation, immunizations, weight man-agement, and contraception. A new chapter to this section is T ravel Medicine. This is a growing area, and we felt readers of this text need to have an understanding of the complexity of world travel and how it affects pharmacotherapy. Unit 14—Women’s Health This is a new unit in the third edition. We felt that there is a growing emphasis on Women’s Health and that compiling the chapters relevant to this area of study would assist the learner in recognizing the special nature of care that this population deserves. Unit 15—Integrative Approach to Patient Care While there are only two chapters in this unit, they represent the culmination of the text. Practitioners need to have an understanding of the economics of pharmacotherapeutics in order to effectively prescribe medications and treat patients. With the ever-increasing costs of pharmaceuticals and the introduction of far-sweeping legislation, such as Medicare Part D, the practitioner needs to be fully aware of the systems in place that facilitate, or hinder, a patient’s access to medications. This chapter discusses the economics of therapeutics, includ-ing formularies, co-pays, prior authorizations, and Medicare as well as managed care as it applies to prescribing medications. The last chapter, Integrative Approaches to Pharmaco- therapy, is an attempt to examine real-life, complex cases. Each case addresses the nine questions posed in the individual chap-ter case studies, but now provides the reader with examples of how to approach the case studies and examines issues to consider when presented with more than one diagnosis. These cases are more complex, requiring the reader to think through multiple diseases and therapies instead of a single disorder in isolation. Within this chapter we do offer potential answers to the cases. These may not be the only answers, but indicate some of the thought processes that go into the decision-mak-ing process in the pharmacologic management of a problem. Chapter Organization The book offers a consistent approach throughout each disor-der chapter. The chapter format begins with the background and pathophysiology of the disorder, followed by a discussion of the relevant classes of drugs. These broad categories are then integrated in the section on Selecting the Most Appropriate Agent. Drug overview tables are also organized consistently, giv- ing the reader much information on each drug, including the usual dose, contraindications and side effects, and any special considerations a prescriber should be aware of during therapy. All of this information is supported by the significant text. Algorithms provide the reader with a visual cue on how to approach treating a patient. Recommended order of treatment tables provide the reader with basic drug therapy selection, from first-line to third-line therapies for each disorder. These, coupled with the algorithms and the drug tables, are the core of the text. A case study is provided for each disorder discussed. These short cases are designed to stimulate discussion among students and with instructors. The nine questions at the end of each case are tailored to each disorder, but remain similar across all cases to reinforce the process of thinking pharmaco-therapeutically. Pharmacotherapeutics for Advanced Practice is intended to pro- vide primary care students with a reasoned approach to learn-ing pharmacotherapeutics and to serve as a reference for the seasoned practitioner. As experienced educators and practitio-ners, we are dedicated to providing you with a textbook that will meet your needs. Virginia Poole Arcangelo Andrew M. Peterson Arcangelo_FM.indd viiiArcangelo_FM.indd viii 10/8/2011 2:55:32 PM10/8/2011 2:55:32 PMixCONTRIBUTORS Angela A. Allerman, PharmD, BCPS Clinical Pharmacy Specialist Department of Defense Pharmacoeconomic CenterFort Sam Houston, TX Chapter 49: Anticoagulation Disturbances Kelly Barranger, MSN, RN, CRNP Department of Veteran’s AffairsPhiladelphia, PA Chapter 19: HypertensionChapter 50: Anemias Anemias John Barron, BS Pharmacy, PharmD Executive DirectorHealth Plan ResearchHealthCore, Inc.Wilmington, DE Chapter 20: Hyperlipidemia Laura L. Bio, PharmD, BCPS Assistant Professor in Clinical Pharmacy, PediatricsDepartment of Pharmacy Practice and Pharmacy Administration University of the SciencesPhiladelphia, PAClinical Pediatric Pharmacy SpecialistDepartment of PharmacyCooper University HospitalCamden, NJ Chapter 18: Otitis Media and Otitis Externa Tim A. Briscoe, PharmD, CDE Clinical Pharmacist SpecialistColumbus Regional Health SystemColumbus, GA Chapter 3: Impact of Drug Interactions and Adverse Events on Therapeutics Debra Carroll, MSN, CRNP Gerontological Nurse PractitionerTri-Valley Primary CareTelford, PA Chapter 6: Principles of Pharmacotherapy in Elderly PatientsQuinn A. Czosnowski, PharmD, BCPS Assistant Professor of Clinical PharmacyPharmacy Practice and Pharmacy AdministrationPhiladelphia College of PharmacyUniversity of the SciencesPhiladelphia, PAClinical Pharmacist, Intensive Care UnitCooper University HospitalCamden, NJ Chapter 39: Seizure Disorders Lauren M. Czosnowski, PharmD, BCPS Assistant Professor of Clinical PharmacyDepartment of Pharmacy Practice/Pharmacy AdministrationPhiladelphia College of PharmacyUniversity of the SciencesInternal Medicine Clinical Specialist PharmacyHospital of the University of PennsylvaniaPhiladelphia, PA Chapter 47: Allergies and Allergic Reactions Elyse L. Dishler, MD Karen S. Harkaway Dermatology Delran, NJ Chapter 38: Headaches Amy M. Egras, PharmD, BCPS Assistant ProfessorDepartment of Pharmacy PracticeThomas Jefferson University, Jefferson School of Pharmacy Clinical PharmacistJefferson Family Medicine AssociatesThomas Jefferson University HospitalPhiladelphia, PA Chapter 54: Weight Loss Heather E. Fean, MSN, APN-C Nurse PractitionerAdvocare Gigliotti Family MedicineBerlin, NJ Chapter 22: Heart Failure Kelleen N. Flaherty, MS Assistant ProfessorBiomedical WritingUniversity of the Sciences in PhiladelphiaPhiladelphia, PA Chapter 38: Headaches Arcangelo_FM.indd ixArcangelo_FM.indd ix 10/8/2011 2:55:33 PM10/8/2011 2:55:33 PMx CONTRIBUTORS Maria Foy, PharmD, CPE Clinical Coordinator, Pharmacy Department Abington Memorial HospitalAbington, PA Chapter 7: Principles of Pharmacology in Pain ManagementChapter 14: Bacterial Infections of the Skin Stephanie A. Gaber, PharmD, CDE Clinical CoordinatorDepartment of PharmacyThomas Jefferson University Hospital—Methodist DivisionPhiladelphia, PA Chapter 5: Principles of Pharmacotherapy in Pregnancy and Lactation Jomy M. George, PharmD, BCPS Assistant Professor in Clinical PharmacyDepartment of Pharmacy Practice and Pharmacy Administration University of the SciencesPhiladelphia, PAClinical Pharmacist—Infectious Disease/HIVDepartment of PharmacyCooper University HospitalCamden, NJ Chapter 18: Otitis Media and Otitis Externa Ellen Boxer Goldfarb, CRNP Outpatient CoordinatorJefferson Antithrombic ServicesThomas Jefferson Internal Medicine AssociatesPhiladelphia, PA Chapter 49: Anticoagulation Disturbances Andrew J. Grimone, PharmD, RPh, BCPS Assistant ProfessorDepartment of NursingClarion University of PennsylvaniaOil City, PAClinical Pharmacy ManagerDepartment of PharmacySaint Vincent Health CenterErie, PA Chapter 8: Principles of Antimicrobial Therapy Emily R. Hajjar, PharmD, BCPS, CGP Associate ProfessorJefferson School of PharmacyThomas Jefferson UniversityPhiladelphia, PA Chapter 44: Alzheimer’s Disease Andrea M. Heise, MSN, APN-C Nurse PractitionerAdvocare Gigliotti Family MedicineBerlin, NJ Chapter 22: Heart FailureLauren K. McCluggage, PharmD, BCPS Assistant ProfessorDepartment of Pharmacy Practice and Pharmacy Administration Philadelphia College of Pharmacy, University of the SciencesClinical Pharmacy Specialist—Internal MedicineDepartment of PharmacyHospital of the University of PennsylvaniaPhiladelphia, PA Chapter 36: Osteoarthritis and Rheumatoid Arthritis Carol Gullo Mest, PhD, RN, ANP-BC Associate ProfessorDirector of Graduate Nursing ProgramsDeSales UniversityCenter Valley, PA Chapter 36: Osteoarthritis and Rheumatoid Arthritis Samir K. Mistry, PharmD Corporate Vice President of PharmacyAveta, Inc.Fort Lee, NJ Chapter 59: The Economics of Pharmacotherapeutics Angela Cafiero Moroney, PharmD Senior Clinical Science ManagerGlobal Pharmaceutical Research and DevelopmentAbbott LaboratoriesAbbott Park, IL Chapter 44: Alzheimer’s Disease Betty E. Naimoli, MSN, CRNP Adjunct ProfessorFrances M. Maguire School of NursingGwynedd-Mercy CollegeGwynedd Valley, PANurse PractitionerHealth Physicians NetworkAbington Memorial HospitalAbington, PA Chapter 37: Fibromyalgia Jessica O’Hara, PharmD Medical WriterAston, PA Chapter 54: Weight Loss Dharmi Patel, PharmD Clinical PharmacistHome SolutionsHorsham, PA Chapter 43: Attention-Deficit/Hyperactivity Disorder Jeegisha R. Patel, PharmD Assistant Professor of Clinical Pharmacy Philadelphia College of Pharmacy University of the Sciences in Philadelphia Chapter 52: Smoking Cessation Arcangelo_FM.indd xArcangelo_FM.indd x 10/8/2011 2:55:33 PM10/8/2011 2:55:33 PMxi CONTRIBUTORS Louis R. Petrone, MD Clinical Assistant Professor Family and Community MedicineJefferson Medical CollegeAttending PhysicianFamily and Community MedicineThomas Jefferson University HospitalPhiladelphia, PA Chapter 46: Thyroid Disorders Jennifer A. Reinhold, BA, PharmD, BCPS Assistant Professor of Clinical PharmacyDepartment of Pharmacy Practice/Pharmacy AdministrationPhiladelphia College of PharmacyUniversity of the SciencesPhiladelphia, PAClinical PharmacistQuality Family PhysiciansHockessin, DE Chapter 34: Overactive BladderChapter 40: Major Depressive Disorder Alicia M. Reese, PharmD, MS, BCPS Assistant Professor of Clinical PharmacyPhiladelphia College of Pharmacy University of the SciencesPhiladelphia, PA Chapter 21: Chronic Stable Angina Cynthia A. Sanoski, BS, PharmD, BCPS, FCCP Chair and Associate ProfessorDepartment of Pharmacy PracticeJefferson School of PharmacyThomas Jefferson UniversityPhiladelphia, PA Chapter 23: Arrhythmias Matthew Sarnes, PharmD Vice PresidentXcendaPalm Harbor, FL Chapter 3: Impact of Drug Interactions and Adverse Events on Therapeutics Jason J. Schafer, PharmD, BCPS, AAHIVE Assistant ProfessorDepartment of Pharmacy PracticeJefferson School of PharmacyThomas Jefferson UniversityPhiladelphia, PA Chapter 14: Bacterial Infections of the Skin Susan M. Schrand, MSN, CRNP Executive DirectorPennsylvania Coalition of Nurse PractitionersJenkintown, PA Chapter 37: FibromyalgiaHenry M. Schwartz, BSc Pharm, PharmD, CDE Assistant Professor of Clinical PharmacyDirector of Community Pharmacy ExperiencesPharmacy Practice and Pharmacy AdministrationPhiladelphia College of PharmacyUniversity of the SciencesPhiladelphia, PA Chapter 53: Travel Medicine Anita Siu, PharmD Clinical Associate ProfessorPharmacy Practice and AdministrationErnest Mario School of Pharmacy Rutgers, The State University of New JerseyPiscataway, NJNeonatal/Pediatric Pharmacotherapy SpecialistDepartment of PharmacyK. Hovnanian Children’s Hospital at Jersey Shore University Medical Center Neptune, NJ Chapter 4: Principles of Pharmacotherapy in Pediatrics Joshua J. Spooner, PharmD, MS Assistant Dean for Student AffairsCollege of PharmacyWestern New England UniversitySpringfield, MA Chapter 17: Ophthalmic DisordersChapter 59: The Economics of Pharmacotherapeutics Linda M. Spooner, PharmD, BCPS Associate Professor of Pharmacy PracticeDepartment of Pharmacy PracticeMassachusetts College of Pharmacy and Health SciencesBoston, MAClinical Pharmacy Specialist in infectious DiseasesDepartment of PharmacySaint Vincent HospitalWorcester, MA Chapter 48: Human Immunodeficiency Virus Liza Takiya, PharmD, BCPS Associate DirectorU.S. Medical InformationPfizer, IncCollegeville, PA Chapter 31: Inflammatory Bowel Disease Jim Thigpen, PharmD, BCPS Assistant ProfessorDepartment of Pharmacy PracticeBill Gatton College of PharmacyEast Tennessee State UniversityClinical PharmacistDepartment of Pharmacy ServicesNiswonger Children’s HospitalJohnson City, TN Chapter 4: Principles of Pharmacotherapy in Pediatrics Arcangelo_FM.indd xiArcangelo_FM.indd xi 10/8/2011 2:55:33 PM10/8/2011 2:55:33 PMxii CONTRIBUTORS Tyan F. Thomas, PharmD, BCPS Assistant Professor of Clinical Pharmacy Pharmacy Practice and Pharmacy AdministrationPhiladelphia College of PharmacyUniversity of the SciencesClinical PharmacistPhiladelphia Veterans’ Affairs Medical CenterPhiladelphia, PA Chapter 52: Smoking Cessation Craig B. Whitman, PharmD, BCPS Assistant Professor of Clinical PharmacyPharmacy Practice and Pharmacy AdministrationPhiladelphia College of PharmacyUniversity of the SciencesPhiladelphia, PAClinical Pharmacist, Intensive Care UnitCooper University HospitalCamden, NJ Chapter 39: Seizure DisordersVeronica F. Wilbur, PhD, FNP-BC Chair, Nurse Practitioner ProgramCollege of Health Professions—Graduate NursingWilmington UniversityNew Castle, DE Chapter 30: Constipation, Diarrhea, and Irritable Bowel Syndrome Chapter 42: Insomnia and Sleep DisordersChapter 45: Diabetes Mellitus Eric T. Wittbrodt, PharmD Field Scientific LeadScientific StrategiesTakeda Pharmaceuticals America, Inc.Deerfield, IL Chapter 27: Bronchitis and Pneumonia Arcangelo_FM.indd xiiArcangelo_FM.indd xii 10/8/2011 2:55:33 PM10/8/2011 2:55:33 PMxiiiACKNOWLEDGMENTS We would like to thank the following reviewers, who provided valuable feedback on several chapters in the third edition: Lynda K. Ball, MSN, RN, CNN Quality Improvement DirectorNorthwest Renal NetworkSeattle, Washington Barbara A. Broome, PhD, RN, FAAN Associate Dean College of Nursing and Chair Community/ Mental Health University of South Alabama – College of NursingMobile, Alabama Shelley Yerger Hawkins, DSN, APRN-BC, FNP, GNP, FAANP Senior Director, Clinical Team Celgene CorporationLos Angeles, CaliforniaLinda Ludwig, RN, BS, MEd Clinical ConsultantKingfisher, Oklahoma Diane Orlov, CNP, RN, BS, MS Nurse PractitionerThe Ohio State University Medical CenterDivision of Infectious DiseasesColumbus, Ohio We would also like to thank the people at Lippincott Williams & Wilkins, including Bill Lamsback and Rosanne Hallowell, as well as Amy Furman, Copy Editor. We are also forever indebted to the contributors and reviewers who spent countless hours working on this project. Without them, this would never have become a reality. In addition, we would like to thank our families who supported us throughout the project and understand of the importance of this book to us. Arcangelo_FM.indd xiiiArcangelo_FM.indd xiii 10/8/2011 2:55:33 PM10/8/2011 2:55:33 PMArcangelo_FM.indd xivArcangelo_FM.indd xiv 10/8/2011 2:55:33 PM10/8/2011 2:55:33 PMxvCONTENTS Preface vii Contributors ixAcknowledgments xiii UNIT 1 Principles of Therapeutics 1 1 Issues for the Practitioner in DrugTherapy 2 Virginia P . Arcangelo 2 Pharmacokinetic Basis of Therapeutics and Pharmacodynamic Principles 15 Andrew M. Peterson 3 Impact of Drug Interactions and Adverse Events on Therapeutics 30 Tim A. Briscoe, Matthew Sarnes, & Andrew M. Peterson 4 Principles of Pharmacotherapy in Pediatrics 49 Anita Siu & Jim Thigpen 5 Principles of Pharmacotherapy in Pregnancy and Lactation 60 Stephanie A. Gaber & Andrew M. Peterson 6 Principles of Pharmacotherapy in Elderly Patients 66 Debra Carroll 7 Principles of Pharmacology in Pain Management 79 Maria Foy & Andrew M. Peterson 8 Principles of Antimicrobial Therapy 96 Andrew J. Grimone 9 Complementary and Alternative Medicine 118 Virginia P . Arcangelo 10 Pharmacogenomics 127 Andrew M. Peterson UNIT 2 Pharmacotherapy for Skin Disorders 133 11 Contact Dermatitis 134 Virginia P . Arcangelo 12 Fungal Infections of the Skin 141 Virginia P . Arcangelo 13 Viral Infections of the Skin 150 Virginia P . Arcangelo 14 Bacterial Infections of the Skin 158 Jason J. Schafer & Maria Foy 15 Psoriasis 173 Virginia P . Arcangelo 16 Acne Vulgaris and Rosacea 183 Virginia P . Arcangelo UNIT 3 Pharmacotherapy for Eye and Ear Disorders 195 17 Ophthalmic Disorders 196 Joshua J. Spooner 18 Otitis Media and Otitis Externa 217 Laura L. Bio & Jomy M. George UNIT 4 Pharmacotherapy for Cardiovascular Disorders 229 19 Hypertension 230 Kelly Barranger Arcangelo_FM.indd xvArcangelo_FM.indd xv 10/8/2011 2:55:33 PM10/8/2011 2:55:33 PM