(Test Bank) Clayton’s Basic Pharmacology for Nurses

Willihnganz,Gurevitz,Clayton, 19

Nursing

Test Bank

19th Edition

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Test Bank for Clayton’s Basic Pharmacology for Nurses, The downloadable file consists of 331 pages, and the total size of the file is 2.75 MB. Purchase now only for highly discounted price.

Author(s): Willihnganz, Gurevitz, Clayton

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Study Note Preview

Chapter 01: Drug Definitions, Standards, and Information Sources Willihnganz: Clayton’s Basic Pharmacology for Nurses, 19th Edition MULTIPLE CHOICE 1. Which name identifies a drug listed by the US Food and Drug Administration (FDA)? a. Brand b. Nonproprietary c. Official d. Trademark ANS: C The official name is the name under which a drug is listed by the FDA. The brand name, or trademark, is the name given to a drug by its manufacturer. The nonprop rietary, or generic, name is provided by the United States Adopted Names Council. DIF: Cognitive Level: Knowledge REF: p. 9 OBJ: 1 NAT: NCLEX Client Needs Category: Safe, Effective Care Environment TOP: Nursing Process Step: Assessment CON: Patient Educat ion 2. Which source contains information specific to nutritional supplements? a. USP Dictionary of USAN & International Drug Names b. Natural Medicines Comprehensive Database c. United States Pharmacopoeia/National Formulary (USP NF) d. Drug Interaction Facts ANS: C United States Pharmacopoeia/National Formulary contains information specific to nutritional supplements. USP Dictionary of USAN & International Drug Names is a compilation of drug names, pronunciation guide, and possible future FDA approved drugs; it does not include nutritional supplements. Natural Medicines Comprehensive Database contains evidence -based information on herbal medicines and herbal combinati on products; it does not include information specific to nutritional supplements. Drug Interaction Facts contains comprehensive information on drug interaction facts; it does not include nutritional supplements. DIF: Cognitive Level: Knowledge REF: p. 4 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Nutrition | Patient Education 3. Which drug reference contains drug monographs that describe all drugs in a therapeutic class? a. Drug Facts and Comparisons b. Drug Interaction Facts c. Handbook on Injectable Drugs d. Martindale —The Complete Drug Reference ANS: A Drug Facts and Comparisons contains drug monographs that describe all drugs in a therapeutic class. Monographs are f ormatted as tables to allow comparison of similar products, brand names, manufacturers, cost indices, and available dosage forms Online version is available. DIF: Cognitive Level: Knowledge REF: p. 4 Table 1.2 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Safety | Patient Education | Clinical Judgment 4. Which drug reference contains monographs about virtually every single -entity drug available in the United St ates and describes therapeutic uses of drugs, including approved and unapproved uses? a. Martindale: The Complete Drug Reference b. AHFS Drug Information c. Drug Reference d. Drug Facts and Comparisons ANS: B AHFS Drug Information contains monographs about virtually every single -entity drug available in the United States and describes therapeutic uses of drugs, including approved and unapproved uses. DIF: Cognitive Level: Knowledge REF: p. 4 Table 1.2 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Planning CON: Safety | Patient Education | Clinical Judgment 5. Which online drug reference makes available to healthcare providers and the public a standard, comprehen sive, up -to-date look up and downloadable resource about medicines? a. American Drug Index b. American Hospital Formulary c. DailyMed d. Drug Reference ANS: C DailyMed makes available to healthcare providers and the public a standard, comp rehensive, up-to-date look up and downloadable resource about medicines. The American Drug Index is not appropriate for patient use. The American Hospital Formulary is not appropriate for patient use. The drug reference is not appropriate for patient use. DIF: Cognitive Level: Knowledge REF: p. 3 | p. 4 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Safety | Patient Education | Clinical Judgment 6. Which legislation authorizes the FDA to determine the safety of a drug before its marketing? a. Federal Food, Drug, and Cosmetic Act (1938) b. Durham Humphrey Amendment (1952) c. Controlled Substances Act (1970) d. Kefauver Harris Drug Amendment (1962) ANS: A The Federal Food, Drug, and Cosmetic Act of 1938 authorized the FDA to determine the safety of all drugs before marketing. Later amendments and acts helped tighten FDA control and ensure drug safety. The Durham Humphrey Amendment defines the kinds of drugs that cannot be used safely without medical supervision and restricts their sale to prescription by a licensed practitioner. The Controlled Substances Act addresses only controlled substances and their categorization. The Kefauver Harris Drug Amendment ensures drug efficacy and greater drug safety. Drug manufacturers are required to prove to the FDA the effectiveness of their products before marketing them. DIF: Cognitive Level: Knowledge REF: p. 5 Table l.3 OBJ: 5 NAT: NCLEX Client Needs C ategory: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Safety | Patient Education | Evidence | Health Care Law 7. Which classification does meperidine (Demerol) fall under? a. I b. II c. III d. IV ANS: B Meperidine (Demerol) is a Schedule II drug; it has a high potential for abuse and may lead to severe psychological and physical dependence. Schedule I drugs have high potential for abuse and no recognized medical use. Schedule III drugs have some potential for abuse. Use may lead to low to moderate physical dependence or high psychological dependence. Schedule IV drugs have low potential for abuse. Use may lead to limited physical or psychological dependence. DIF: Cognitive Level: Knowledge REF: p. 10 OBJ: 2 NAT: NCLEX Client Needs Category: Safe, Effective Care Environment TOP: Nursing Process Step: Assessment CON: Patient Education | Addiction | Pain 8. Which action would the FDA take to expedite drug development and approval for an outbreak of smallpox ? a. List smallpox as a health orphan disease. b. Omit the preclinical research phase. c. Extend the clinical research phase. d. Fast track the investigational drug. ANS: D Once the Investigational New Drug Application has been approved, the drug can receive highest priority within the agency, which is called fast tracking. A smallpox outbreak would become a priority concern in the world. Orphan diseases are not researched in a priority manner. Preclinical research is not omitted. Extending any phase of the research would mean a longer time to develop a vaccine. The FDA must ensure that all phases of the preclinical and clinical research phase have been completed in a safe man ner. DIF: Cognitive Level: Knowledge REF: p. 7 OBJ: 5 NAT: NCLEX Client Needs Category: Safe, Effective Care Environment TOP: Nursing Process Step: Assessment CON: Health Care Law | Health Care Policy | Infection | Care Coordination 9. Which statement is true about over -the-counter (OTC) drugs? a. They are not listed in the USP NF . b. A prescription from a healthcare provider is needed. c. They are sold without a prescription. d. They are known only by their brand names. ANS: C OTC medications do not require a prescription. A variety of names, both generic and trade, can be used for individual drugs sold OTC. OTC drugs are listed in the USP NF . Prescription drugs require an order by a health professional who is licensed to prescr ibe, such as a physician, nurse practitioner, physician assistant, or dentist. DIF: Cognitive Level: Comprehension REF: p. 2 OBJ: 2 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Planning CON: Patient Education 10. Which is the most authoritative reference for medications that are injected? a. Martindale: The Complete b. Handbook on Injectable Drugs c. DailyMed d. Handbook of Nonprescription Drugs ANS: B The Handbook on Injectable Drugs is the most comprehensive reference available on the topic of compatibility of injectable drugs. It is a collection of monographs for more than 300 injectable drugs that are listed alphabetically by generic name. DIF: Cognitive Level: Knowledge REF: p. 4 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Clinical Judgment | Safety 11. Which statement is true about Lomotil? a. Abuse potential for this drug is low. b. Psychological dependency is likely. c. There is a high potential for abuse. d. This drug is not a controlled substance. ANS: A Lomotil, a Schedule V drug, has an abuse potential of limited physical or psycho logical dependence liability compared with drugs in Schedule IV. Because abuse potential is low with a Schedule V drug, a prescription may not be required. Psychological dependency is not likely with a Schedule V drug. Schedule V drugs are classified as co ntrolled substances. DIF: Cognitive Level: Knowledge REF: p. 5 Box 1.1 OBJ: 2 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Clinical Judgment | Safety | Patient Education 12. Which medication order ed for a patient with a substance abuse history has the greatest risk for abuse? a. Lomotil b. Diazepam c. Phenobarbital d. Lortab ANS: D Lortab is a Schedule III drug with a high potential for abuse but less so than d rugs in Schedules I and II. Lomotil is a Schedule V drug with a low potential for abuse compared with those in Schedule V. Diazepam is a Schedule IV drug with a low potential for abuse compared with those in schedule III. Phenobarbital is a Schedule IV dru g with a low potential for abuse compared with those in Schedule III. DIF: Cognitive Level: Application REF: p. 5 Box 1.1 OBJ: 2 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Addiction | Patient Education | Safety 13. An older adult experiencing shortness of breath is brought to the hospital by her daughter. While obtaining the medication history from the patient and her daughter, the nurse discovers that neither has a list o f the patient‘s current medications or prescriptions. The patient has is a weekly pill dispenser that contains four different pills. The prescriptions are filled through the local pharmacy. Which resource would be appropriate to use in determining the medi cation names and doses? a. Martindale —The Complete Drug Reference b. Drugs and Facts Comparisons c. Senior citizens‘ center d. Patient‘s home pharmacy ANS: D The patient‘s pharmacy would have an accurate account of all the medications the client is currently taking. Martindale —The Complete Drug Reference has written information on medications and would not be an appropriate resource. Drugs and Facts Comparisons contains drug monographs that describe all drugs in a therapeutic class but wou ld not help identify medications by photograph. The senior citizens‘ center is not likely to have specific patient medication information. DIF: Cognitive Level: Application REF: p. 2 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Care Coordination | Safety | Patient Education | Clinical Judgment MULTIPLE RESPONSE 1. Which statement(s) will be included when planning patient teaching regarding drug names? (Select all that apply. ) a. Most drug companies place their products on the market under generic names. b. The official name is the name under which the drug is listed by the US Food and Drug Administration (FDA). c. Brand names are easier to pronounce, spell, and remember. d. The first letter of the generic name is not capitalized. e. The chemical name is most meaningful to the patient. ANS: B, C, D The official name is the name under which the drug is listed by the FDA. Brand names are easier to pronounce, spell, and remem ber. The first letter of the generic name is not capitalized. Most drug companies place their products on the market under brand names instead of generic names. The chemical name is most meaningful to the chemist. DIF: Cognitive Level: Comprehension REF: p. 2 | p. 9 OBJ: 1 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Planning CON: Patient Education | Clinical Judgment | Safety 2. Which drug(s) would be considered to be in the category Schedule II? ( Select all that apply. ) a. Marijuana b. Percodan c. Amphetamines d. Fiorinal e. Flurazepam ANS: B, C Schedule II drugs have a high potential for abuse, they are currently accepted in the United States, and use may lead to severe psychological or physical depende nce. Percodan and amphetamines are considered Schedule II drugs. Marijuana is a Schedule I drug. Fiorinal is a Schedule III drug. Flurazepam is a Schedule IV drug. DIF: Cognitive Level: Comprehension REF: p. 5 Box 1.1 OBJ: 2 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Addiction | Clinical Judgment | Patient Education Chapter 02: Basic Principles of Drug Action and Drug Interactions Willihnganz: Clayton’s Basic Pharmacology for Nurses, 19th Edition MULTIPLE CHOICE 1. Which priority action should be implemented when hives are assessed on a patient started on a new medication? a. Notify physician of allergic reaction. b. Notify physician of idiosyncratic reaction. c. Notify physician of potential teratogenicity. d. Notify physician of potential tolerance. ANS: A An allergic reaction is indicative of hypersensitivity and manifests with hives and/or urticaria, which are easily identified. An idiosyncratic reaction occurs when something unusual or abnormal happens when a drug is first administered. A teratogenic reac tion refers to the occurrence of birth defects related to administration of the drug. Tolerance refers to the body‘s requirement for increasing dosages to achieve the same effects that a lower dose once did. DIF: Cognitive Level: Application REF: p. 17 OBJ: 4 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Clinical Judgment | Safety 2. The nurse administers an initial dose of a steroid to a patient with asthma. Thi rty minutes after administration, the nurse finds the patient agitated and stating that ―everyone is out to get me.‖ Which term is used for this unusual reaction? a. Desired action b. Adverse effect c. Idiosyncratic reaction d. Allergic reaction ANS: C Idiosyncratic reactions are unusual, abnormal reactions that occur when a drug is first administered. Patients typically exhibit an overresponsiveness to a medication related to diminished metabolism. These reactions are believed to be related to geneti c enzyme deficiencies. Desired actions are expected responses to a medication. Adverse effects are reactions that occur in another system of the body; they are usually predictable. Allergic reactions appear after repeated medication dosages. DIF: Cognitiv e Level: Knowledge REF: p. 18 OBJ: 4 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Evaluation CON: Patient Education | Clinical Judgment | Caregiving | Safety | Sensory Perception 3. Which is the best description of when drug interactions occur? a. On administration of toxic dosages of a drug b. On an increase in the pharmacodynamics of bound drugs c. On the alteration of the effect of one drug by another drug d. On increase of drug excretion ANS: C Drug interactions may be characterized by an increase or decrease in the effectiveness of one or both of the drugs. Toxicity of one drug may or may not affect the metabolism of another one. Drug interactions may result from either increased or decreased ph armacodynamics. Drug interactions may result from either increased or decreased excretion. DIF: Cognitive Level: Comprehension REF: p. 18 OBJ: 5 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Safety | Patient Education | Clinical Judgment 4. Which term describes when two drugs compete for the same receptor site, resulting in increased activity of the first drug? a. Desired action b. Synergistic effect c. Carcinogenicity d. Displacement ANS: D The displacement of the first drug from receptor sites by a second drug increases the amount of the first drug because more unbound drug is available. An expected response of a drug is the desired action. A synergistic effect is the effect of two dr ugs being greater than the effect of each chemical individually or the sum of the individual effects. Carcinogenicity is the ability of a drug to cause cells to mutate and become cancerous. DIF: Cognitive Level: Knowledge REF: p. 19 OBJ: 6 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Safety | Patient Education 5. What do drug blood levels indicate? a. They confirm if the patient is taking a generic form of a drug. b. They determine if the patient has sufficient body fat to metabolize the drug. c. They verify if the patient is taking someone else‘s medications. d. They determine if the amount of drug in the body is in a therapeutic range. ANS: D The amount of drug present may vary over time and the blood level must remain in a therapeutic range in order to obtain the desired result. Generic drugs do not necessarily produce a different drug blood level than proprietary medications. Body fat is not measured by drug blood levels. Drug blood levels only measure the amount of drug in the body; they do not determine the source of the medication. DIF: Cognitive Level: Comprehension REF: p. 17 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integri ty TOP: Nursing Process Step: Evaluation CON: Clinical Judgment | Safety 6. What is the process by which a drug is transported by circulating body fluids to receptor sites? a. Osmosis b. Distribution c. Absorption d. Biotransformation ANS: B Distribution refers to the ways in which drugs are transported by the circulating body fluids to the sites of action (receptors), metabolism, and excretion. Osmosis is the process of moving solution across a semipermeable membrane to equalize the dilution on each side. Absorption is the process by which a drug is transferred from its site of entry into the body to the circulating fluids for distribution. Biotransformation, also called metabolism, is the process by which the body inactivates drugs. DIF: Cognitive Level: Knowledge REF: p. 15 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Planning CON: Patient Education | Clinical Judgment | Safety 7. Which blood level is assessed to determine the amount of circu lating medication in a patient? a. Peak b. Trough c. Drug d. Therapeutic ANS: C When a drug is circulating in the blood, a blood sample may be drawn and assayed to determine the amount of drug present; this is known as the drug blood level. Peak levels are only those drug blood levels that are at their maximum before metabolism starts to decrease the amount of circulating drug. Trough levels are only those drug blood levels that are at their minimum when metabolism has decreased the amount of circulating drug and before an increase caused by a subsequent dose of the medication. Therapeutic levels are only those within a prescribed range of blood levels determined to bring about effective action of the medication. DIF: Cognitive Level: Knowledge REF: p. 17 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Evaluation CON: Patient Education | Clinical Judgment | Safety 8. The nurse administers 50 mg of a drug at 6:00 AM that has a half -life of 8 hours. What time will it be when 25 mg of the drug has been eliminated from the body? a. 8:00 AM b. 11:00 AM c. 2:00 PM d. 6:00 PM ANS: C Fifty percent of the medication, or 25 mg, will be eliminated in 8 hours, or at 2:00 PM. 8:00 AM is 2 hours after administration; the half -life is 8 hours. 11:00 AM is 4 hours after administration; the half -life is 8 hours. 6:00 PM is 12 hours after administration; the half -life is 8 hours. DIF: Cognitive Level: Analysis REF: p. 16 OBJ: 2 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Evaluation CON: Clinical Judgment | Safety | Elimination | Health Promotion 9. What will the nurse need to determine first in order to mix two drugs in the sam e syringe? a. Absorption rate of the drugs b. Compatibility of the drugs c. Drug blood level of each drug d. Medication adverse effects ANS: B Knowledge of absorption is important but not in order to mix drugs. In order to mix two drugs, compatibility is determined so there is no deterioration when the drugs are mixed in the same syringe. Drug level does not indicate if it is acceptable to mix medications in the same syringe. Adverse effects are important for the nurse to kn ow but not in order to mix drugs. DIF: Cognitive Level: Application REF: p. 19 OBJ: 5 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Clinical Judgment | Safety 10. A patient developed hives and itching after receiving a drug for the first time. Which instruction by the nurse is accurate? a. Stop the medication and encourage the patient to wear a medical alert bracelet that explains the allergy. b. Explain to the patient that these are signs and symptoms of an anaphylactic reaction. c. Emphasize to the patient the importance to inform medical personnel that in the future a lower dosage of this drug is necessary. d. Instruct the patient that it woul d be safe to take the drug again because this instance was a mild reaction. ANS: A This initial allergic reaction is mild, and the patient is more likely to have an anaphylactic reaction at the next exposure; a medical alert bracelet is necessa ry to explain the reaction. Signs and symptoms of an anaphylactic reaction are respiratory distress and cardiovascular collapse. A more severe reaction will occur at the next exposure, and the patient should not receive the drug again. DIF: Cognitive Leve l: Application REF: p. 18 OBJ: 4 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Patient Education | Clinical Judgment | Safety 11. Which assessment data would the nurse identify as having the m ost effect on drug metabolism? a. History of liver disease b. Intake of a vegetarian diet c. Sedentary lifestyle d. Teacher as an occupation ANS: A Liver enzyme systems are the primary site for metabolism of drugs. Intake of a v egetarian diet may affect absorption but not metabolism. Sedentary lifestyle and occupations could affect metabolism (exposure to environmental pollutants), but these do not have the most significant effect on metabolism. DIF: Cognitive Level: Comprehension REF: p. 15 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Patient Education | Clinical Judgment | Safety 12. A physician‘s order indicates to administer a medica tion to the patient via the percutaneous route. Which route will the nurse anticipate the patient will receive this medication? a. Intramuscularly b. Subcutaneously c. Topically d. Rectally ANS: C The percutaneous route refers to drugs that are absorbed through the skin and mucous membranes. Methods of the percutaneous route include inhalation, sublingual (under the tongue), or topical (on the skin) administration. The parenteral route bypasses the gastrointestinal (GI) tract by using subcutaneous (subcut), intramuscular (IM), or intravenous (IV) injection. The parenteral route bypasses the GI tract by using subcut, IM, or IV injection. In the enteral route, the drug is administered directly into the GI tract by the oral, rectal, or nasogastric route. DIF: Cognitive Level: Comprehension REF: p. 14 OBJ: 1 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Patient Education | Clinical Judgment | Safety 13. Which medication should not be administered with tetracycline? a. Ativan b. Tylenol c. Colace d. Mylanta ANS: D Administering tetracycline with Mylanta can provide an antagonistic effect that will result in decreased absorption of the tetracycline. Ativan, Tylenol, and Colace are not contraindicated to administer with tetracycline. DIF: Cognitive Level: Comprehension REF: p. 18 OBJ: 5 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Patient Education | Clinical Judgment | Safety MULTIPLE RESPONSE 1. Which statement(s) about liberation of drugs is/are true? ( Select all that apply. ) a. A drug must be dissolved in body fluids before it can be absorbed into body tissues. b. A solid drug taken orally must disintegrate and dissolve in GI fluids to allow for absorption into the bloodstream for transport to the site of action. c. The process of converting the drug into a soluble form can be controlled to a certain degree by the dosage form. d. Converting the drug to a soluble form can be influenced by administering the drug with or without food in the patient‘s stomach. e. Elixirs take longer to be liberated from the dosage form. ANS: A, B, C, D Regardless of the route of administration, a drug must be dissolved in body fluids before it can be absorbed into body tissues. Before a solid drug taken orally can be absorbed in to the bloodstream for transport to the site of action, it must disintegrate and dissolve in the GI fluids and be transported across the stomach or intestinal lining into the blood. The process of converting a drug into a soluble form can be partially cont rolled by the pharmaceutical dosage form used (e.g., solution, suspension, capsules, and tablets with various coatings). The conversion process can also be influenced by administering the drug with or without food in the patient‘s stomach. Elixirs are alre ady drugs dissolved in a liquid and do not need to be liberated from the dosage form. DIF: Cognitive Level: Comprehension REF: p. 14 OBJ: 1 | 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Patient Education | Clinical Judgment | Safety 2. Which are routes of drug excretion? ( Select all that apply. ) a. GI tract, feces b. Genitourinary (GU) tract, urine c. Lymphatic system d. Circulatory system, blood/plasma e. Respiratory system, exhalation ANS: A, B, E The GI system is a primary route for drug excretion. The GU and the respiratory systems do function in the excretion of drugs. The lymphatic and circulatory syst ems are involved with drug distribution, not drug excretion. DIF: Cognitive Level: Knowledge REF: p. 15 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Patient Education | Clinical Judgment | S afety | Elimination 3. Which route(s) enable(s) drug absorption more rapidly than the subcut route? ( Select all that apply. ) a. IV route b. IM route c. Inhalation/sublingual d. Intradermal route e. Enteral route ANS: A, B, C IV route of administration enables drug absorption more rapidly than the subcut route. IM route of administration enables drug absorption more rapidly because of greater blood flow per unit weight of muscle. Inhalation/sublingual route of administration en ables drug absorption more rapidly than the subcut route. Intradermally administered drugs are absorbed more slowly because of the limited available blood supply in the dermis. Enterally administered drugs are absorbed more slowly because of the biotransfo rmation process. DIF: Cognitive Level: Knowledge REF: p. 14 OBJ: 1 | 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Evaluation CON: Patient Education | Clinical Judgment | Safety 4. Which factor(s) contribute(s) to digoxin toxicity in a 92 -year-old patient? ( Select all that apply. ) a. Taking the medication with meals b. Prolonged half -life of the drug digoxin c. Impaired renal function d. Diminished mental capacity ANS: B, C Impai red renal and hepatic function in older adults impairs metabolism and excretion of drugs, thus prolonging the half -life of a medication. Food would decrease the absorption of the drug. Diminished mental capacity does not contribute to drug toxicity unless it is due to administration errors. DIF: Cognitive Level: Comprehension REF: p. 15 OBJ: 2 | 3 NAT: NCLEX Client Needs Category: Health Promotion and Maintenance TOP: Nursing Process Step: Assessment CON: Patient Education | Clinical Judgment | Safety 5. Which statement(s) about variables that influence drug action is/are true? ( Select all that apply. ) a. An older adult will require increased dosage of a drug to achieve the same therapeutic effect as that seen in a younger person. b. Body weight can affe ct the therapeutic response of a medication. c. Chronic smokers may metabolize drugs more rapidly than nonsmokers. d. A patient‘s attitude and expectations affect the response to medication. e. Reduced circulation causes drugs to absorb more rapidly. ANS: B, C, D Body weight can affect response to medications; typically, obese patients require an increase in dosage and underweight patients a decrease in dosage. Chronic smoking enhances metabolism of drugs. Attitudes and expectations play a major role in an individual‘s response to drugs. Older adults require decreased dosages of drugs to achieve a therapeutic effect. Decreased circulation causes drugs to absorb more slowly. DIF: Cognitive Level: Comprehension REF: p. 17 OBJ: 4 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Patient Education | Clinical Judgment | Safety 6. Which factor(s) affect(s) drug actions? ( Select all that apply. ) a. Teratogenicity b. Age c. Body weight d. Metabolic rate e. Illness ANS: B, C, D, E Age, body weight, metabolic rate, and illness may contribute to a variable response to a medication. Teratogenicity does not contribute to a variable response to a medication. DIF: Cognitive Level: Knowledge REF: p. 17 OBJ: 3 | 4 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Patient Education | Clinical Judgment | Safety COMPLETION 1. A patient receives 200 mg of a medication that has a half -life of 12 hours. How many mg of the drug would remain in the patient‘s body after 24 hours? _____ ANS: 50 The half -life is defined as the amount of time required for 50% of the drug to be eliminated from the body. If a patient is given 200 mg of a drug that has a half -life of 12 hours, then 50 mg of the drug would remain in the body after 24 hours. DIF: Cognitive Level: Analysis REF: p. 16 OBJ: 2 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Evaluation CON: Clinical Judgment | Safety Chapter 03: Drug Action Across the Life Span Willihnganz: Clayton’s Basic Pharmacology for Nurses, 19th Edition MULTIPLE CHOICE 1. What time will the trough blood level need to be drawn if the nurse administers the intravenous medication dose at 9:00 AM? a. 6:30 AM b. 8:30 AM c. 9:30 AM d. 11:30 AM ANS: B Trough blood levels measure the lowest blood level of medicine and are obtained just before the dose is administered. In this case, 6:30 AM is too early to obtain the blood level. The other two times occur after the medication is administered. DIF: Cognitive Level: Application REF: p. 28 OBJ: 3 NAT: NCLEX Client Needs Category: Physi ological Integrity TOP: Nursing Process Step: Implementation CON: Clinical Judgment | Safety 2. What will the nurse expect the healthcare provider‘s order to be when starting an older adult patient on thyroid hormone replacement therapy? a. Administering a loading dose of the drug b. Directions on how to taper the drug c. A dosage that is one -third to one -half of the regular dosage d. A dosage that is double the regular dosage ANS: C To prevent toxicity, dosages for new medications in older adults should be one -third to one-half the amount of a standard adult dosage. Loading doses of drugs could cause severe toxicity. Tapering off is characteristic of discontinuation of medications and is not appropriate for this situation. Older adults generally need a lower medication dosage than younger patients. DIF: Cognitive Level: Comprehension REF: p. 31 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step : Implementation CON: Clinical Judgment | Safety | Patient Education | Development 3. Which drugs cause birth defects? a. Teratogens b. Carcinogens c. Metabolites d. Placebos ANS: A Teratogens are drugs that cause birth defects. Carcinogens cause cancer. Metabolites are the end product of metabolism. Placebos are drugs that have no pharmacologic activity. DIF: Cognitive Level: Knowledge REF: p. 31 OBJ: 5 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Clinical Judgment | Safety | Patient Education | Development 4. Which life -threatening illness may occur as a result of aspirin (salicylate) administration during viral illness to patients younger than 20 years of age? a. Anaphylactic shock b. Reye‘s syndrome c. Chickenpox d. Influenza A ANS: B Children are susceptible to Reye‘s syndrome if they ingest aspirin at the time o f or shortly after a viral infection of chickenpox or influenza. Anaphylactic shock is caused by a hypersensitivity reaction. Chickenpox is the result of being infected with a virus. Influenza A is caused by a pathogen. DIF: Cognitive Level: Knowledge REF: p. 30 OBJ: 3 NAT: NCLEX Client Needs Category: Physiological Integrity TOP: Nursing Process Step: Implementation CON: Clinical Judgment | Safety | Patient Education | Development 5. Which classification of medications commonly causes allergic re actions in children? a. Antacids b. Analgesics c. Antibiotics d. Anticonvulsants ANS: C Antibiotics, especially penicillins, commonly cause allergic reactions in children. Intravenous antibiotics can cause rapid reactions; therefore, the pediatric p atient‘s response to a medication should be assessed and monitored closely. Antacids rarely cause allergic reactions. Children are not particularly allergic to analgesics or anticonvulsants. DIF: Cognitive Level: Knowledge REF: p. 29 OBJ: 3 NAT: NCLEX Cli ent Needs Category: Physiological Integrity TOP: Nursing Process Step: Assessment CON: Clinical Judgment | Safety | Patient Education | Development 6. Which patient statement indicates the need for further teaching after giving ins tructions to an expectant mother about taking medications during pregnancy? a. ―I will not take herbal medicines during pregnancy.‖ b. ―For morning sickness, I will try crackers instead of taking a drug.‖ c. ―If I get a cold, I will avoid taking nonpresc ription medications until I check with my physician.‖ d. ―I will limit my alcohol intake to only one glass of wine weekly.‖ ANS: D